Wild Card loss to Buffalo Bills in the 2021 season
The Patriots' 47-17 loss to the Buffalo Bills in the Wild Card round of the 2021 postseason was, without a doubt, the most embarrassing loss of the 21st century for the Patriots.
The Bills did not punt in the game, and Josh Allen threw for 308 yards and five touchdowns.
An underlying story in that game was how it showed the shift in the dominance of the Patriots.
The embarrassing blowout was precisely what the Patriots used to do to teams in the opening rounds of the playoffs with Tom Brady. The Bills effectively gave the Patriots a taste of their own medicine.