Patriots vs. Cowboys prediction, odds, spread, injuries, trends for NFL Week 4

The New England Patriots got their first win of the season in Week 3, taking down the New York Jets by a final score of 15-10.

Now, they'll face a tough challenge in the Dallas Cowboys, who are coming off an upset loss to the Arizona Cardinals as 12.5-point favorites.

I'm going to give you my best bet for the game in this article, but if you want my picks for the rest of the Week 4 slate, check out the latest edition of the "Road to 272 Bets."

One of the best strategies you should utilize when betting on the NFL is to have accounts at as many sportsbooks as possible to ensure you're always receiving the best odds. That's why you should make sure to sign up at WynnBET Sportsbook before this weekend's games. It's the best sportsbook for true Patriots fans.

Now, let's jump into the betting preview with all odds coming from WynnBET.

Patriots vs. Cowboys odds, spread and total

Spread:

• Patriots +7 (-125)
• Cowboys -7 (+105)

Moneyline:

• Patriots +225
• Cowboys -270

Total:

• 43 (Over -110/Under -110)

Patriots vs. Cowboys betting trends

• Patriots are 1-6 ATS in their last seven games
• Patriots are 6-1 straight up in their last seven games vs. Cowboys
• Patriots are 6-1 ATS in their last seven games played in October
• The UNDER is 8-2 in the last 10 meetings between these two teams
• Cowboys are 4-10 ATS in their last 14 games played in Week 4
• The OVER is 5-0 in the Cowboys' last five games

Patriots vs. Cowboys injury reports

New England Patriots injury report

• Davon Godchaux - DT - Questionable
• Cole Strange - G - Questionable
• Jonathan Jones - CB - Questionable
• Sidy Sow - G - Questionable
• Daniel Ekuale - DT - Injured Reserve

Dallas Cowboys injury report

• Trevon Diggs - CB - Injured Reserve
• Tyron Smith - OT - Questionable
• Tyler Biadasz - C - Questionable
• Zack Martin - G - Questionable

Patriots vs. Cowboys how to watch

• Date: Sunday, Oct. 1
• Game Time: 4:25 p.m. EST
• Venue: AT&T Stadium
• How to Watch (TV): FOX
• New England Patriots Record: 1-2
• Dallas Cowboys Record: 2-1

Patriots vs. Cowboys key players to watch

New England Patriots

Ezekiel Elliott: Zeke will be facing his former team, the Dallas Cowboys, in this matchup. He's coming off his best performance of the season, gaining 80 yards on 16 carries against the Jets. He's also been the more effective runner for the Patriots this season, averaging 4.4 yards per carry compared to 2.9 for Rhamondre Stevenson. He's poised for a big game against his former squad.

Dallas Cowboys

Michael Gallup: The Cowboys are searching for who will be the number two target at the wide receiver position for them this season. CeeDee Lamb is their No. 1 guy, but Michael Gallup and Brandin Cooks are battling for the No. 2 spot. They both have 11 targets, but Gallup has hauled in eight receptions compared to just four for Cooks.

Patriots vs. Cowboys prediction and pick

I made the claim this week that the Dallas Cowboys are the most fraudulent team in the NFL. Despite being 2-1 with both their wins coming in blowout victories, I don't think this team is nearly as good as people think.

Their two big wins in the first two weeks are largely due to offensive and special teams blunders from their opponents. Their underlying metrics aren't promising either, ranking just 12th in Net Yards per Play ahead of Week 4.

Let's also take into consideration the fact the Patriots might just be the best team they've faced so far this season. The Giants aren't the same team as they were last year, the Jets are a mess without a quarterback, and the Cardinals were supposed to be the worst team in the league.

The Patriots can match them defensively and you may be surprised to see them become more effective on offense as well.

I don't just like the Patriots to cover as 7-point underdogs. I like them to win this game outright in a significant upset.

Pick: Patriots +225

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!