In what will undoubtedly be the final trip to his hometown Bay Area as an active player, Tom Brady will lead the Patriots into Levi’s Stadium against a team ill-equipped to stop him. The 49ers are dead last in the league on defense, allowing 31.3 points per game. Look for the Patriots to score early and often.
As for the other sideline, the Chip Kelly experiment is off to a rocky start in San Francisco. He’s without a bona fide quarterback capable of running his system, leaving the 49ers offense sputtering from week-to-week with few answers. Even at home, there’s likely little this team can do to keep up with the high-octane New England attack.
Tom Brady would rather have played in this stadium last February, but he’ll gladly take the win in this affair.
Prediction: New England 38, San Francisco 17