Saints vs. Patriots prediction, odds, spread, injuries, trends for NFL Week 5

Giving you a full betting preview, including odds and trends, for NFL Week 5 action between the New Orleans Saints and New England Patriots.

Oct 1, 2023; Arlington, Texas, USA;  New England Patriots tight end Mike Gesicki (88) cannot catch a
Oct 1, 2023; Arlington, Texas, USA; New England Patriots tight end Mike Gesicki (88) cannot catch a / Tim Heitman-USA TODAY Sports

The New England Patriots and New Orleans Saints both suffered tough losses in Week 4 of the NFL season, and now they'll meet each other in an interconference showdown in Week 5.

In this article, we're going to give you everything you need to know to bet on this game, including the odds, trends, key players, and my best bet.

Before we dive into it, be sure to place your bets at WynnBET Sportsbook, an absolute must for any and all bettors in Massachusetts.

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Now, let's dive into the odds.

Saints vs. Patriots odds, spread, and total


  • Saints +2 (-110)
  • Patriots -2 (-110)


  • Saints +112
  • Patriots -130


  • 39.5 (Over -110/Under -110)

Saints vs. Patriots betting trends

  • Saints are 0-4-1 ATS in their last five games
  • The UNDER is 10-0 in the Saints' last 10 games
  • Saints are 8-3 ATS in their last 11 games vs. Patriots
  • Patriots are 1-7 TS in their last eight games
  • Patriots are 0-5 ATS in their last five home games

Saints vs. Patriots injury reports

New Orleans Saints injury report

  • Foster Moreau - TE - Questionable
  • Juwan Johnson - TE - Questionable
  • Lonnie Johnson Jr. - CB - Questionable
  • Andrus Peat - G - Questionable

New England Patriots injury report

  • Jonathan Jones - CB - Questionable
  • Jonathan Jones - CB - Questionable
  • Matthew Judon - LB - Doubtful
  • Tyrone Wheatley Jr. - Questionable

Saints vs. Patriots how to watch

  • Date: Sunday, October 8
  • Game Time: 1:00pm et
  • Venue: Gillette Stadium
  • How to Watch (TV): CBS
  • New Orleans Saints Record: 2-2
  • New England Patriots Record: 1-3

Saints vs. Patriots key players to watch

New England Patriots

Hunter Henry: The top receiving option for the Patriots is Hunter Henry, who leads the team in both receptions (17) and yards (176). If the Patriots want to gain some level of momentum and move the ball against the Saints, Henry is going to play a big role in that.

New Orleans Saints

Alvin Kamara: After missing the first three games, Alvin Kamara immediately played a massive role in the Saints offense in Week 4. He averaged 4.6 yards per carry on 11 rushes and then added in 13 receptions for 33 yards through the air. Their offenses moving forward is going to continue to rely on Kamara.

Saints vs. Patriots prediction and pick

I don't think there's any question how we need to bet on this game. The UNDER has hit in 10 straight games for the Saints, and now they face a team that has a lot of similarities to them in the Patriots.

Heading into Week 4, the Patriots and Saints rank 24th and 29th respectively in yards per play. Meanwhile, they rank sixth and eighth in opponent yards per play. Both squads are all defense and no offense.

I expected more from the Derek Carr in New Orleans, but it hasn't worked out that way, plus he has a nagging shoulder injury. Now, the Saints have to play the best defense they've faced this season. I see no reason why the Patriots won't be able to shut them down. Let's remember, they haven't score more than 17 points in a single game this season.

Give me the UNDER in this interconference matchup.

Pick: UNDER 39.5 (-110)

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Odds refresh periodically and are subject to change.

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