Welcome to the initial MusketFire.com staff projections for the upcoming New England Patriots game. Week one kicks off with the Patriots on the road in Buffalo, NY to face the Buffalo Bills. Last season, the Patriots had a field day running the ball against Buffalo, but with the Bills importing former New York Jets defensive coordinator Mike Pettine and his Rex Ryan hybrid 3-4 defense, the Bills expect to be much improved against the running game this season. This week, the Patriots face a depleted Bills secondary, as the Bills lost top cornerback Stephon Gilmore to injury for the first half of the season, inexplicably let safety George Wilson walk this offseason, and with disgruntled safety Jairus Byrd possibly not suiting up, the Patriots may be spending a lot of time attacking by air. On offense, the Bills have rookie quarterback E.J. Manuel healthy enough to start, but no one on the New England defense will be sleeping on explosive running back C.J. Spiller. What does the future hold for Sunday afternoon? Well, the dedicated staff at MusketFire.com has it covered. Here are the staff predictions for the Patriots versus the Bills matchup in week one of the NFL season!